We fight infectious disease !
Publications
From 2018
2024
Hwang S+, Heo BE+, Nguyen TQ+, Kim YJ+, Lee SG, Huynh TH, Kim E, Jo SI, Baek MJ, Shin EK, Oh J, Park C, Yoon YJ, Park EJ, Kim KT, Ryoo S, Lee DG, Wood C, Woo M, Kim DD, Paik S*, Jo EK*, Jang J*, Oh DC*, ”Arenicolide Family Macrolides Provide a New Therapeutic Lead Combating Multidrug-resistant Tuberculosis", Angew Chem Int Ed Engl, doi: 10.1002/anie.202412994.
Sapkota A, Park EJ, Kim YJ, Heo JB, Nguyen TQ, Heo BE, Kim JK, Lee SH, Kim SI, Choi YJ, Roh T, Jeon SM, Jang M, Heo HJ, Whang J, Paik S, Yuk JM, Kim JM, Song GY*, Jang J*, Jo EK*, “The autophagy-targeting compound V46 enhances antimicrobial responses to Mycobacteroides abscessus by activating transcription factor EB”, Biomed Pharmacother, doi: 10.1016/j.biopha.2024.117313.
Huynh TH, Kim HK, Lee J, Ban YH, Jang YJ, Heo BE, Nguyen TQ, An JS, Kwon Y, Nam SJ, Jang J, Oh KB, Shin MK, Oh DC, “Retinestatin, a Polyol Polyketide from a Termite Nest-Derived Streptomyces sp”, J Nat Prod, doi: 10.1021/acs.jnatprod.3c01043.
Nguyen TQ, Heo BE, Jeon S, Ash A, Lee H, Moon C, Jang J, “Exploring antibiotic resistance mechanisms in Mycobacterium abscessus for enhanced therapeutic approaches”, Front Microbiol, doi: 10.3389/fmicb.2024.1331508.
2023
Huynh TH, Bae ES, Heo BE, Lee J, An JS, Kwon Y, Nam SJ, Oh KB, Jang J, Lee SK, Oh DC, "Tandocyclinones A and B, Ether Bridged C-Glycosyl Benz[a]anthracenes from an Intertidal Zone Streptomyces sp", Mar Drugs, doi: 10.3390/md21090500.
Nguyen TQ, Heo BE, Hanh BTB, Jeon S, Park Y, Choudhary A, Lee S, Kim TH, Moon C, Min SJ, Jang J, "DS86760016, a Leucyl-tRNA Synthetase Inhibitor, Is Active against Mycobacterium abscessus", Antimicrob Agents Chemother, doi: 10.1128/aac.01567-22., Editor's Pick !
Nguyen TQ, Heo BE, Park Y, Jeon S, Choudhary A, Moon C, Jang J, "CRISPR Interference-Based Inhibition of MAB_0055c Expression Alters Drug Sensitivity in Mycobacterium abscessus", Microbiol Spectr, doi: 10.1128/spectrum.00631-23.
Kim YJ, Park EJ, Lee SH, Silwal P, Kim JK, Yang JS, Whang J, Jang J, Kim JM, Jo EK, "Dimethyl itaconate is effective in host-directed antimicrobial responses against mycobacterial infections through multifaceted innate immune pathways", Cell Biosci, doi: 10.1186/s13578-023-00992-x.
2022
Huynh TH, Lee J, Moon DH, Nguyen TQ, Son S, Hwang S, Du YE, Cui J, Jang JH, Nam SJ, Shin J, Jang J, Lee SK, Oh KB, Oh DC, "Gwanakosides A and B, 6-Deoxy-α-l-talopyranose-Bearing Aromatic Metabolites from a Streptomyces sp. and Coculture with Pandoraea sp", J Nat Prod, doi: 10.1021/acs.jnatprod.1c00703.
Jeon SM, Kim YJ, Nguyen TQ, Cui J, Thi Bich Hanh B, Silwal P, Kim JK, Kim JM, Oh DC, Jang J, Jo EK, "Ohmyungsamycin promotes M1-like inflammatory responses to enhance host defence against Mycobacteroides abscessus infections", Virulence, doi: 10.1080/21505594.2022.2138009.
Nguyen TQ, Hanh BTB, Jeon S, Heo BE, Park Y, Choudhary A, Moon C, Jang J, "Synergistic Effect of Q203 Combined with PBTZ169 against Mycobacterium tuberculosis", Antimicrob Agents Chemother, doi: 10.1128/aac.00448-22.
Cui J, Kim E, Moon DH, Kim TH, Kang I, Lim Y, Shin D, Hwang S, Du YE, Song MC, Bae M, Cho JC, Jang J, Lee SK, Yoon YJ, Oh DC, "Taeanamides A and B, Nonribosomal Lipo-Decapeptides Isolated from an Intertidal-Mudflat-Derived Streptomyces sp", Mar Drugs, doi: 10.3390/md20060400.
Kim JS, Kim HK, Cho E, Mun SJ, Jang S, Jang J, Yang CS, "PE_PGRS38 Interaction With HAUSP Downregulates Antimycobacterial Host Defense via TRAF6", Front Immunol, doi: 10.3389/fimmu.2022.862628.
Heo J, Koh D, Woo M, Kwon D, de Almeida Falcão VC, Wood C, Lee H, Kim K, Choi I, Jang J, Brodin P, Shum D, Delorme V, "A combination screening to identify enhancers of para-aminosalicylic acid against Mycobacterium tuberculosis", Sci Rep, doi: 10.1038/s41598-022-08209-w.
2021
Bich Hanh BT, Quang NT, Park Y, Heo BE, Jeon S, Park JW, Jang J,"Omadacycline Potentiates Clarithromycin Activity Against Mycobacterium abscessus", Front Pharmacol, doi: 10.3389/fphar.2021.790767.
Quang NT, Jang J, "Current Molecular Therapeutic Agents and Drug Candidates for Mycobacterium abscessus", Front Pharmacol, doi: 10.3389/fphar.2021.724725.
Shin YH, Ban YH, Kim TH, Bae ES, Shin J, Lee SK, Jang J, Yoon YJ, Oh DC, "Structures and Biosynthetic Pathway of Coprisamides C and D, 2-Alkenylcinnamic Acid-Containing Peptides from the Gut Bacterium of the Carrion Beetle Silpha perforata", J Nat Prod, doi: 10.1021/acs.jnatprod.0c00864.
An JS, Shin B, Kim TH, Hwang S, Shin YH, Cui J, Du YE, Yi J, Nam SJ, Hong S, Shin J, Jang J, Yoon YJ, Oh DC, "Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp", Org Lett, doi: 10.1021/acs.orglett.1c00847.
Kim T, Hanh BT, Heo B, Quang N, Park Y, Shin J, Jeon S, Park JW, Samby K, Jang J, "A Screening of the MMV Pandemic Response Box Reveals Epetraborole as a New Potent Inhibitor against Mycobacterium abscessus", Int J Mol Sci, doi: 10.3390/ijms22115936.
2020
Kim YJ, Lee SH, Jeon SM, Silwal P, Seo JY, Hanh BTB, Park JW, Whang J, Lee MJ, Heo JY, Kim SH, Kim JM, Song GY, Jang J, Jo EK,"Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis", Virulence, doi: 10.1080/21505594.2020.1809961.
Hanh BTB, Kim TH, Park JW, Lee DG, Kim JS, Du YE, Yang CS, Oh DC, Jang J, "Etamycin as a Novel Mycobacterium abscessus Inhibitor", Int J Mol Sci, doi: 10.3390/ijms21186908.
Hwang S, Shin D, Kim TH, An JS, Jo SI, Jang J, Hong S, Shin J, Oh DC, "Structural Revision of Lydiamycin A by Reinvestigation of the Stereochemistry", Org Lett, doi: 10.1021/acs.orglett.0c01110. Epub 2020 Apr 24.
Hanh BTB, Park JW, Kim TH, Kim JS, Yang CS, Jang K, Cui J, Oh DC, Jang J, "Rifamycin O, An Alternative Anti-Mycobacterium abscessus Agent", Molecules, doi: 10.3390/molecules25071597.
Kim YS, Kim JK, Hanh BTB, Kim SY, Kim HJ, Kim YJ, Jeon SM, Park CR, Oh GT, Park JW, Kim JM, Jang J, Jo EK, "The Peroxisome Proliferator-Activated Receptor α- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections", Cells, doi: 10.3390/cells9030648.
2019
Kim TH, Hanh BTB, Kim G, Lee DG, Park JW, Lee SE, Kim JS, Kim BS, Ryoo S, Jo EK, Jang J, "Thiostrepton: A Novel Therapeutic Drug Candidate for Mycobacterium abscessus Infection", Molecules, doi: 10.3390/molecules24244511.
Kim E, Shin YH, Kim TH, Byun WS, Cui J, Du YE, Lim HJ, Song MC, Kwon AS, Kang SH, Shin J, Lee SK, Jang J, Oh DC, Yoon YJ, "Characterization of the Ohmyungsamycin Biosynthetic Pathway and Generation of Derivatives with Improved Antituberculosis Activity", Biomolecules, doi: 10.3390/biom9110672.
Bouvier G, Simenel C, Jang J, Kalia NP, Choi I, Nilges M, Pethe K, Izadi-Pruneyre N, "Target Engagement and Binding Mode of an Antituberculosis Drug to Its Bacterial Target Deciphered in Whole Living Cells by NMR", Biochemistry, doi: 10.1021/acs.biochem.8b00975. Epub 2019 Jan 3.
2018
Jeong J, Kim G, Moon C, Kim HJ, Kim TH, Jang J, "Pathogen Box screening for hit identification against Mycobacterium abscessus", PLoS One, doi: 10.1371/journal.pone.0195595. eCollection 2018.
Hur J, Jang J, Sim J, Son WS, Ahn HC, Kim TS, Shin YH, Lim C, Lee S, An H, Kim SH, Oh DC, Jo EK, Jang J, Lee J, Suh YG, "Conformation-Enabled Total Syntheses of Ohmyungsamycins A and B and Structural Revision of Ohmyungsamycin B", Angew Chem Int Ed Engl, doi: 10.1002/anie.201711286. Epub 2018 Feb 21.